EDUCATIONAL SERIES – RED SERIES NEW TRENDS IN CLINICAL ONCOLOGY Recommendations of a group of experts for the pathological assessment of tumour regression of liver metastases of colorectal cancer and damage of non-tumour liver tissue after neoadjuvant therapy

Colorectal cancer (CRC) incidence has increased during the past decades in Spain, being the first malignant tumour in incidence. Observed mortality for CRC is mainly due to liver and lung metastases. The only curative treatment is surgery; new surgical techniques and neoadjuvant treatments have increased the number of surgery candidate patients. Patients should be managed with a multidisciplinary approach that includes imaging techniques, chemotherapy, surgery and pathological assessment. As an answer to this approach, a group of pathology experts interested on CRC liver metastases aimed to review the diagnosis and prognosis of liver mestastases and developed practical recommendations for its assessment. The expert group revised the current literature and prepared questions to be discussed based on available evidence and on their clinical practise. As a result, recommendations for the assessment of tumour regression of liver metastases are This manuscript has been endorsed by the Sociedad Española de Anatomı́a Patológica. M. L. Gómez Dorronsoro (&) Servicio de Anatomı́a Patológica, Hospital de Navarra, C/de Irunlarrea 3, 31008 Pamplona, Spain e-mail: [email protected] R. Vera Departamento de Oncologı́a, Hospital de Navarra, Pamplona, Spain L. Ortega Servicio de Anatomı́a Patológica, Hospital Clı́nico San Carlos, Madrid, Spain C. Plaza F. López-Rios Laboratorio de Dianas Terapéuticas, Centro Integral Oncológico ‘‘Clara Campal’’, Hospital HM Universitario Sanchinarro, Madrid, Spain R. Miquel Servicio de Anatomı́a Patológica, Hospital Clı́nic de Barcelona, Barcelona, Spain M. Garcı́a Servicio de Anatomı́a Patológica, Hospital del Mar, Barcelona, Spain E. Dı́az M. R. Ortiz Servicio de Anatomı́a Patológica, Hospital de Girona Dr Josep Trueta, Girona, Spain J. Pérez Servicio de Anatomı́a Patológica, Hospital Universitario la Fe, Valencia, Spain C. Hörndler Departamento de Anatomı́a Patologı́a, Hospital Miguel Servet, Zaragoza, Spain C. Villar Servicio de Anatomı́a Patológica. Hospital Universitario Reina Sofı́a, Córdoba, Spain J. Antúnez Servicio de Anatomı́a Patológica, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain S. Pereira R. González-Cámpora Departamento de Anatomı́a Patológica, Hospital Universitario Virgen Macarena, Sevilla, Spain 123 Clin Transl Oncol DOI 10.1007/s12094-013-1104-3